The modern maternal haemodynamic features for prediction of preeclampsia

Objective. Annually due to PE 500,000 babies and 76,000 mothers had been dying in the world. Preeclampsia (PE) sur­vivors will have at twice the risk of heart disease and stroke, and four times the risk of high blood pressure in the future. The objective is to evaluate the predictive values of the circu­latory syndromes of the cardiovascular system (CVS) induced by gestational endotheliopathy.
Materials and Methods. Investigations of the circulatory syn­dromes of CVS and haemodynamic supporting of pregnan­cy was carried out in the first trimester in 114 women with physiological pregnancy (PhP) and in 132 pregnant women with gestational endotheliopathy (GE). We determined of cir­culatory syndromes by correlation of minute volume of blood while standing/lying – I type (hypokinetic condition) and III type (hyperkinetic condition) of haemodynamics. The haemo­dynamic risk was determined in accordance with the index of haemodynamic nonoptimality (IHN).
Results. According to our investigations the optimization of haemodynamical supporting in PhP was mechanism of vaso­dilator “slippage” of arterial vessels from the systemic vaso­constriction as the haemodynamic equivalent of endothelial activity. The predictors of PE in pregnant women were hyper­kinetic type of circulation (by an anthropo-physiological ratio of standing/lying), integral indicators of functional depreci­ation of the circulatory syndromes of CVS ‒ haemodynamic risk (by IHN > 30%), circulatory syndromes of arterial or ve­nous blood insufficiency in abdominal and pelvic regions.
Conclusions. Our results obtained that the predictors of PE were haemodynamic syndromes of insufficiency and circula­tory limitation in the standing position.