Articles
The association of p16 protein expression with clinicopathology in cervical cancer: a cross-sectional study
Kevin Jitro Frank Noya, Nugraha Utama Pelupessy, Irma Savitri, Upik Miskad 2, Maisuri T Chalid, Sharvianty Arifuddin, Lenny Lisal
, xx-xx
ABSTRACT
Objective. This study aims to analyze the association between p16 protein expression and clinicopathological characteristics in cervical cancer.
Materials and Methods. This cross-sectional study was conducted at Dr. Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital in Makassar, from October 2023 to April 2024. Data were collected from 80 cervical cancer patients. Immunohistochemistry was used to evaluate p16 expression, and the Allred score was applied for classification. Statistical analyses, including the Kruskal-Wallis and Mann-Whitney tests, were used to determine the significance of p16 expression across clinicopathological factors.
Results. Patients ranged from 30 to 82 years old, with the majority presenting with Stage II or III cervical cancer, metastasis, and squamous cell carcinoma histopathology. The analysis revealed a statistically significant correlation between p16 expression and the stage of cervical cancer (p = 0.007) as well as histopathology (p = 0.019), with higher expression in Stage IV and squamous cell carcinoma. However, p16 expression was not significantly associated with clinical symptoms or metastasis.
Conclusions. P16 expression is significantly associated with the stage and histopathological type of cervical cancer, particularly in advanced stages and squamous cell carcinoma. These findings support the potential use of P16 as a prognostic marker for cervical cancer. Further research is recommended to explore p16’s relationship with other clinicopathological
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