The impact of SARS-CoV-2 vaccine on female fertility: a systematic review and meta-analysis


Objective. Most social media users express their fears about vaccine safety as it is believed that SARS-CoV-2 vaccination may affect female reproductive health. The objective of this systematic review and meta-analysis is to evaluate whether WHO-approved SARS-CoV-2 vaccines can affect female fertility.
Materials and Methods. PubMed,, the Cochrane Library, and Google Scholar were systematically searched.
Results. In total, 7 clinical trials were included in systematic review and 6 were included in meta-analysis. Studies evaluated the impact of SARS-CoV-2 vaccine on female fertility. In the first meta-analysis, four studies were included and compared the antral follicle count between the vaccinated and unvaccinated groups: (MD = 0.12, 95% confidence interval (CI): 0.76–1.01, p = 0.78).  The second meta-analysis of two studies compared the AMH level between two groups: (MD = 0.18, 95%CI 0.21–0.57, p = 0.37). The third meta-analysis of three studies compared the number of oocytes between the vaccinated and unvaccinated group: (MD = 0.32, 95%CI 1.36– 0.72, p = 0.55). The fourth meta-analysis of three studies compared the clinical pregnancy rate: (RR = 0.89, 95%CI 0.76–1.03, p = 0.13).
Conclusions. Based on our systematic review and meta-analysis regarding fertility rates in vaccinated against SARS-CoV-2 women and unvaccinated ones, we can conclude that there is no statistically significant difference in these two groups in terms of antral follicle count, AMH level, number of retrieved oocytes and clinical pregnancy rates.

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