The impact of COVID-19 booster vaccination in the current pregnancy during the Omicron waves on maternal and perinatal outcomes: a multicentre observational study


Objective. The aim of this study is to investigate the impact of COVID-19 booster vaccination received during the current pregnancy on maternal and perinatal outcomes.      
Materials and Methods
. This was an observational multicenter study. Pregnant women who gave birth while infected by SARS CoV2 during the Omicron waves were included. Patients were divided into 2 groups: the “booster vaccination” group included pregnant women who had completed vaccination and had received an additional dose of vaccine during pregnancy; the “non-booster vaccination” group included pregnant women who had completed primary vaccination without booster shots. Data about obstetrical and neonatal outcomes in both groups were compared. 
. In total, 59 patients were included: 41 received booster shots during the current pregnancy, and 18 did not. Asymptomatic forms were seen in 58.5% of the “booster vaccination” group versus 16.6% of the “non-boosted vaccination” group with p = 0.003. The need for caesarean delivery was reduced from 72.2% to 41.4% with p = 0.028.  The length of hospitalization was reduced from 4.67 ± 4 days in the “non-boosted vaccination” group to 1.98 ± 0.93 days in the booster vaccination group with p = 0.001. The booster vaccination allowed reduced rates of prematurity with p = 0.011 and neonatal intensive care admissions with p = 0.007.
. The COVID-19 booster vaccination seems to be beneficial during the Omicron waves. It improved obstetrical and neonatal outcomes. So, pregnant women could be advised to get a booster dose of the COVID-19 vaccine when they get pregnant.

Table of Content: Vol. 35 (No. 4) 2023 December

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