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Successful management of Pseudohypoparathyroidism Type 1b in pregnancy: a case report

ABSTRACT

Pseudohypoparathyroidism (PHP) refers to broad spectrum of genetic diseases characterized by the peripheral resistance to parathormone (PTH). This condition leads to hypocalcaemia, hyperphosphatemia and elevated PTH concentrations. There is scant literature on PHP in pregnancy, only nine cases published. The treatment of the disease in pregnant women is challenging. The main target is to avoid hyper/hypocalcemia in order to prevent maternal adverse effects and to protect the development of the fetal parathyroid glands. We report a rare case of PHP type 1b in a pregnant woman, managed by a multidisciplinary team and treated with a tailored therapy.

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