Successful management of Pseudohypoparathyroidism Type 1b in pregnancy: a case report

ABSTRACT
Background. Pseudohypoparathyroidism (PHP) refers to broad spectrum of genetic diseases characterized by the peripheral resistance to parathormone (PTH). This condition leads to hypocalcaemia, hyperphosphatemia and elevated  PTH concentrations. There is scant literature on PHP in pregnancy, only nine cases published. The treatment of the disease in pregnant women is challenging. The main target is to avoid hyper/hypocalcaemia in order to prevent maternal adverse effects and to protect the development of the foetal parathyroid glands.
Case presentation. We report a rare case of PHP type 1b in a pregnant woman, managed by a multidisciplinary team and treated with a tailored therapy.
Conclusions. Good compliance with therapy, regular biochemical and clinical monitoring, and a multidisciplinary management are probably the best way to manage this condition in pregnancy.