Maternal haemodynamic changes in gestational diabetes mellitus (GDM) with or without hypertensive disorders of pregnancy (HDP)

Objective. Maternal haemodynamic maladaptation has been described in pregnancies complicated by GDM or HDP. The aim of our study was to compare haemodynamic features in GDM pregnancies with or without HDP (GDM-HDP versus isolated GDM).
Materials and Methods. A prospective study including 121 GDM patients referred to our unit from 2022 to 2023 was con­ducted. Haemodynamic assessment was performed by Ultra­Sonic Cardiac Output Monitor (USCOM) at three gestational age intervals: 26-30, 32-35, 36-38 weeks.
Results. 11 GDM women developed HDP (9%). There were no differences in anthropometric maternal parameters between the two groups, except for higher maternal age in GDM-HDP group (40.82 ± 7.8 versus 36.73 ± 5.3). No differences were found in OGTT values, glycaemic control, and perinatal outcomes (urgent caesarean section, birth weight, pH < 7, five-minute APGAR < 7, bases excess > 12, neonatal intensive care unit ad­mission). Gestational age at delivery was lower in GDM-HDP group (38.2 ± 0.9 versus 39.1 ± 1.2 weeks). Total vascular resis­tance (TVR) at third USCOM assessment was higher in GDM-HDP group compared to isolated GDM (1,061.60 vs 1,315.09, p = 0.001). At logistic regression, neither maternal age or TVR were independently associated with HDP development in GDM patients.
Conclusions. A worse haemodynamic adaptation to pregnancy, expressed by higher TVR, can be detected in GDM-HDP popu­lation, probably for combined effects of advanced maternal age, high blood pressure and hyperglycaemia on vascular system. This could be helpful in detecting a subgroup of GDM patients with a predisposition to cardiovascular disease in later life.

Table of Content: Vol. 36 (Supplement No. 1) 2024 – Conference Proceedings

Remember that the download is free only for personal use. If you want to utilize articles for large distribution, please contact us at