Impact of COVID-19 vaccination among pregnant women requiring hospital admission: prospective observational research
Objective. The aim of this study was to assess the impact and effectiveness of vaccination among the pregnant population on maternal, obstetrical, and fetal outcomes.
Material and Methods. In this study we included all parturients tested positive for COVID 19 during pregnancy and who needed hospitalization at any stage of gestation. Then, patients were divided into 2 groups according to their vaccination status:
The Vaccinated Group: included pregnant women with completed vaccination by receiving 3 doses of mRNA Vaccine or 2 doses on condition that the second dose received within the last 6 months.
The non-vaccinated group: included pregnant women who had no vaccination against COVID 19.
We collected data about obstetrical and fetal outcomes with 3 months of follow-up.
Results. 145 parturients were admitted for COVID 19 in the maternity of Sfax in Tunisia. The vaccinated group included 45 patients and the non-vaccinated group included 100 patients. Demographic parameters were comparable in both groups. The vaccination reduced the rate of hospitalization in Intensive care units from 23% to 4.3%; p < 0.001. Cesarean section delivery was seen in 56 cases from 76 patients who delivered while infected (73%) versus 11 cases from 33 who delivered in the vaccinated group (33.3%) with p < 0.001. The vaccination reduced the risk of prematurity from 35% to 6.6% with p < 0.001. No cases of vertical transmission were noted in either group.
Conclusions. Pregnant women seem to be protected from severe forms and severe complications of COVID 19. Obstetrical and neonatal outcomes appear to be improved with vaccination.