First trimester haemodynamic profiles in pregnant women at high- and low- risk for preeclampsia

Objective. The aim of our study was to evaluate maternal hae­modynamic profile assessed by USCOM in women resulted at high and low risk for preeclampsia (PE) at first trimester screening.
Materials and Methods. This was a prospective monocentric observational study analysing maternal haemodynamic pro­file assessed by USCOM in 459 pregnant women at the time of first trimester screening for preeclampsia.
Continuous variables were compared using t-test student, while the chi-square or Fisher’s test were used for categori­cal variables. A P-value of < 0.05 was considered statistically significant.
Results. In our cohort, 123 women reported a high-risk result (26.8%). Out of them, 21.9% developed PE and only the 2.2% of low-risk women did. Heart Rate (HR) (83.62 ± 15.43 vs 87.24 ± 19.24; p = 0.045), Systemic Vascular Resis­tance Index (SVRI) (3,208.07 ± 1,270.97 vs 3,681.32 ± 1,808; p = 0.010), Systemic Vascular Resistance Index (SVR) z-score (1.79 ± 1.48 vs 2.27 ± 1.35; p = 0.001) and Potential Kinetic Ratio (PKR) (81.29 ± 45.52 vs 92.91 ± 53.41; p = 0.036) were significantly higher in high-risk women compared to low-risk group. Otherwise, Stroke Volume (SV) and Stroke Vol­ume Index (SVI) are both higher in low risk resulted women (46.96 ± 14.68 vs 44.19 ± 15.30; p = 0.047 and 26.81 ± 8.32; p ≤ 0.001, respectively).
Conclusions. Pregnant women classified as low and high risk at first trimester screening for PE reported two different maternal haemodynamic profile. According to our results, in high-risk women, an unfavourable haemodynamic profile could be highlighted in the first trimester. Further studies can lead to the introduction of USCOM markers in a more com­plex predictive model of PE.

Table of Content: Vol. 36 (Supplement No. 1) 2024 – Conference Proceedings

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