Efficacy of treatment of HPV-related CIN1 with a vaginal spray composed of Carboxymethyl glucan – Curcumin – Resveratrol – Epicatechin gallate (CCREg): a preliminary study

ABSTRACT   

Objective. HPV-related Cervical Intraepithelial Neoplasia (CIN) lesions require several years to evolve into invasive forms and can often regress spontaneously; according to the current national guidelines, patients aged between 25-64 undergo screening examinations with either a PAP Test (under 30 years of age, every 3 years) or HPV-DNA Test (above 30 years of age, every 5 years); if HPV test is positive, a confirmatory PAP Test is required. In the case of CIN1 lesions, patients undergo check-ups every 12 months to monitor possible changes; if the lesion does not regress within 24 months from the diagnosis, cervical conization is performed.
A mixture of Carboxymethyl glucan, Curcumin, Resveratrol, and Epicatechin gallate (CCREg) in the form of a vaginal spray can support reepithelization and provide antioxidant, anti-inflammatory, and antitumoral effects.
Materials and Methods. 90 patients diagnosed with CIN1 lesions between the age of 25 and 55 were included in the study and divided into two groups: 45 patients underwent treatment with CCREg vaginal spray and 45 did not undergo any therapy for a 6-month period. Within each group, three age subgroups were identified (25-35 years old; 36-45 years old; 46-55 years old) in order to stratify the results.
Results. The patients that used the CCREg vaginal spray had a higher spontaneous regression rate compared to the control group in all age subgroups, in particular among patients aged between 25-35.
Conclusions. Thanks to its antioxidant, anti-inflammatory, and antitumoral effects, CCREg vaginal spray can favor a higher probability of regression of CIN1 lesions.