Could elevated serum prolactin positively impact pregnancy outcomes in females undergoing IVF/ICSI?

ABSTRACT
Objective. Optimal reproductive results may need a particular amount of circulating prolactin. ‎Our aim in this study is to assess whether mildly elevated prolactin in females undergoing IVF/ICSI is more effective regarding pregnancy outcomes.
Materials and Methods. A prospective study was conducted on 222 infertile women undergoing IVF/ICSI using the long “gonadotrophin-releasing hormone” (GnRH) agonist protocol‎. Based on their basal prolactin level, 111 women with normal basal prolactin levels (< 25 ng/ml) were allocated to Group 1, and 111 ‎women with basal prolactin levels of 25 to 50 ng/ml were allocated to Group 2. The characteristics of IVF/ICSI cycles and pregnancy outcomes cycles in both groups were recorded.
Results. As expected, the ‎ prolactin level at trigger day showed a significant difference between both groups (64.71 ± 27.74 vs 103.24 ± 29.95, p < 0.001). Although there was no significant difference between both groups regarding the number of oocytes retrieved (p = 0.473), the number of mature oocytes (p = 0.281), the number of total embryos (p = 0.224), and the number of transferred embryos (p = 0.420), the clinical and ongoing pregnancy rates significantly increased in group 2 with mildly elevated basal prolactin level (55.34% with p = 0.034 and 46.60% with p = 0.038, respectively)
Conclusions. Mildly elevated blood prolactin levels (25 to 50 ng/ml) were associated with higher clinical ‎and ongoing pregnancy rates.