Correlation between insulin resistance and hypertensive disorders in pregnant women: a focus on preeclampsia in Italian population

Objective. Aim of our study was to define the role of maternal insulin abnormal metabolism in the pathogenesis of hyper­tensive disorders of pregnancy (HDP) following our previous observation of a lack of insulin-resistance in preeclampsia (PE) of Italian patients.
Materials and Methods. An observational study was con­ducted on 74 pregnant women affected by HDP. Control group was constituted by 20 healthy women with uncompli­cated pregnancy. Fasting insulin, HOMA-IR and QUICKI in­dex score were adopted to measure insulin resistance in both groups.
Results. Before 34 weeks, no significant differences were ob­served in fasting insulin, HOMA-IR, and QUICKI index either among different types of HDP or between women affected by HPD and controls. After 34 weeks, women with chronic hy­pertension compared to controls showed significantly higher levels of fasting insulin, HOMA-IR and QUICKI index (15.47 μUI/ml vs 7.97 μUI/ml, p = 0.02; 2.24 vs 1.39, p = 0.012; 0.34 vs 0.38, p = 0.04). No other differences were found. No differences in insulin-resistance were detected between women with PE and controls and between women with early and late-onset PE.
Conclusions. Hyperinsulinemia and insulin resistance are not features of late-onset preeclampsia in our patients suggesting a different pathogenetic pathways. These findings support the idea of a particular pattern of PE in our country, suggesting a pathogenetic complexity of PE in the various countries.

Table of Content: Vol. 36 (Supplement No. 1) 2024 – Conference Proceedings

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