Carcinoma cervix with synchronous isolated pelvic bone metastasis: a case report and review of literature

ABSTRACT 

Background. Bone metastasis in cervix cancer is uncommon. Its incidence ranges between 1.8%-6.6%. It indicates that the disease is advanced and carries a poor prognosis.
Case presentation. We present a 47-year-old female case of non-keratinizing squamous cell carcinoma cervix with synchronous isolated pelvic bone metastasis. The bone scan was suggestive of metastasis to bilateral pubic bones, ischium, and a suspicious lesion in the right iliac bone. There is no well described management of oligometastatic cervical cancer. Management of metastatic carcinoma cervix is individualized, but palliative chemotherapy is mainly included and has a median survival of about ten months. The presentation, diagnosis of a patient of carcinoma cervix with synchronous isolated pelvic bone metastasis has been discussed. Because of bone metastasis, she was started on palliative chemotherapy (Inj paclitaxel and Inj carboplatin) and zoledronic acid. She has received 4 cycles of palliative chemotherapy and 3 cycles of zoledronic acid so far and has good response.
Conclusions. Synchronous isolated bone metastasis in carcinoma cervix is very rare and is associated with poor prognosis. Appropriate investigations and palliative treatment should be offered.