Assessment of the long Pentraxin 3 level in Polycystic Ovarian Syndrome-related infertility


Objective. To evaluate the role of Pentraxin 3 level in polycystic ovarian syndrome (PCOS)-related infertility and its correlation with the disease’s hormonal profile.
Patients and Methods. A case-control study involves a total of 90 women for one year, 30 women diagnosed with PCOS who are fertile, 30 women diagnosed with PCOS who are infertile, and 30 healthy controls; all women in the early follicular phase were sent for baseline investigations: FSH, LH, AMH, fasting blood sugar, insulin, testosterone, TSH, and Pentraxin 3 that were measured by sandwich electrochemiluminescence immunoassay.
Results. There were statistically significant variations in LH, LH/FSH ratio, testosterone levels, and AMH across the groups. The mean of Pentraxin for the fertile PCOS group (4.14 ± 1.97) ng/mL was significantly higher than for the infertile PCOS group (1.39 ± 1.10 ng/Ml) and control (1.99 ± 1.66 ng/mL). For the infertile PCOS group, the correlation of Pentraxin was significantly positive with age and negative with AMH. ROC Curve analysis showed a cutoff value of 1.05 ng/ml with a sensitivity of 46.67% and specificity of 83.33% for the infertile group.
Conclusions. Pentraxin 3 level is significantly higher in fertile PCOS patients and lower in the infertile PCOS group in comparison to the control group suggesting its possible role in PCOS-related infertility.

Table of Content: Vol. 36 (No. 2) 2024 June

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